A TISSUE RESPONSE TO THE TITANIUM ALLOY (Ti-13Zr-6Nb) IN VIVO
김창수, 이석형,
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김창수 ( Kim Chang-Su ) - 고려대학교의료원 치과보철학교실
이석형 ( Lee Seok-Hyeong ) - 삼성서울병원 치과진료부 보철과
KMID : 0362420040420060619
Abstract
Statement of problem. Mechanisms of tissue-implant interaction and the effect of the implant surface on the behavior of cells has not yet been clarified.
Purpose. This study was performed to investigate the tissue reaction to the titanium alloy submerged into rat peritoneum in vivo.
Materials and methods. Titanium alloys (titanium-13Zirconium-6Niobium) were inserted inside the peritoneal cavity of Sprague Dawley rats. After 3 months, the tissue formed around the inserted titanium alloys were examined with a light-microscope. Tissue reaction around the material was analyzed by confocal microscopy to evaluate their biocompatibility in a living body.
Results. In in vivo study, foreign body type multinucleated giant cells were found in the fibrous tissue formed as a reaction to the foreign material (4 in 20 cases), but the inflammatory reaction was very weak. After experiment, the contaminants of biomaterials was removed from living tissue. In confocal microscopy, we observed that the staining of vinculin and actin showed mixed appearance. In a few cases, we found that the staining of vinculin and beta-catenin showed the prominent appearance.
Conclusion. We found that titanium-13Zirconium-6Niobium alloy was an excellent biomaterial.
키워드
Titanium-13Zirconium-6Niobium alloy;Confocal microscopy;Biocompatibility
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